Regional Research Institute of Unani Medicine

Srinagar, Kashmir

Aim
As a researcher I always try to think out of box. Right now I am actively involved in Drug Standardization Research Work using high end techniques like HPLC, GC/MS, HPTLC, etc. with a vision to generate reliable data in order to provide scientific validation to Unani formulations.

Experience

1. Research Officer (Chemistry): from 2019 till Date.
2. Research Assisstant(Chemistry): 2006- 2019 RRIUM Srinagar
3. Lecturer (Chemistry): 2004-2005. S.P College Srinagar
4. Teaching experience at UG level/PG level: 02 years.

Education

• December 2012 to June2017: PhD (Chemistry) Department of Chemistry, Faculty of Science, National Institute of Technology, Srinagar, India.
• March 2002 to April, 2004: Masters in Chemistry, Faculty of Physical and Material Science, Department of Chemistry, University of Kashmir, Srinagar, India.
• April 1999 to May 2001: Bachelors in Science (1999-2001). S.P. College M.A. Road, University of Kashmir, India.

Current Research Activities

• Pharmacognostic evaluation of Herbal drugs
• Isolation of natural products,
• Characterization of Natural Products.

Technical Skills

1. Column chromatography and TLC
2. HPLC
3. HPTLC
4. GC/MS
5. AAS
6. UV-Visible Spectrometer
7. Rotary evaporator
8. Qualitative and Quantitative estimation of Natural products including;
   1. Terpenes/Terpenoids
   2. Phenolics
   3. Tannins
   4. Alkaloids
   5. Steroids, etc
9. Determination of pharmaceutical parameters like Total ash, Acid insoluble ash, Alcohol soluble matter, Water soluble matter, Moisture content, Heavy/Toxic metals, etc. of crude drugs and formulations.

Collaborative Research with Different Institutions

Publications:

1. Abdul Jalil Shah, Mohammad Younis Dar, MohdAdnan Tanmaykumar Varma Dhairiya Agarwal , Prabha Garg , Reyaz Hassan Mir , Rampratap Meena , Mubashir Hussain Masoodi Integration of phytochemical profiling and computational approaches to evaluate the neuroprotective potential of Nardostachys jatamansi in Alzheimer’s disease. Vol 45, March 2025, e00881
2. Riehana Gani , Bashir Ahmad Sheikh, Rakeeb Ahmad Mir, Basharat Ahmad Bhat, Pervaiz Ahmad Dar, Mohamed Mohany, Mohd Younis Dar and Zulfiqar Ali Bhat. Unravelling the antianxiety activity of various fractions of aerial parts of Salvia moorcroftiana Wall. Ex Benth., by in vivo implicated through computational studies. Natural Product Research.
3. Mohammad Younis Dar*, Md Sajid, Abdul, Riehana Gani, Jalil Shah Rampratap Meena, , Seema Akbar Tariq Ahmad Malik. Pharmaconostic and Phytochemical Charecteristics of the Colchicum luteum Baker (Suranjan) growing wild in Kashmir valley, India.Research Journal of pharmacy and technology(RJPT).2023 ;16(12):5728-1.
4. Mahesh Kancherla, MaryShamya A AtharParvez A, Zaheer AhmedN, Rampratap Meena, Mohammed Younis Dar. Physicochemical, Heavy Metal Analysis, HPTLC, Gas Chromatography-Mass Spectrometry, Antibacterial, and Antioxidant Activity of an Ethanol Extract of Viola pilosa Blume Whole Plant. Journal of Herbal Medicine 2023 42:100812.
5. Wajahat Rashid Mir , Basharat Ahmad Bhat , Ashish Kumar , Rohan Dhiman , Mustfa Alkhanani , Abdullah Almilaibary , Mohd Younis Dar , Showkat Ahmad Ganie , Manzoor Ahmad Mir. Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma. Frontiers in Pharmacology 2023:14:1135898
6. Muhammad Younus Dar, Tabassum Ara, and Seema Akbar. A New Prenylated Coumarin from Daphne oleoides and its cytotoxic activity Chemistry of Natural Compounds, Vol. 55, No. 1, January, 2019
7. Muhammad Younus Dar, TabassumAra, Seema Akbar. Isolation of Daphnetin 8- methyl etherfrom Daphne oleoidesand its Antibacterial activity. The Journal of Phytopharmacology 2015; 4(4): 224-226. ISSN 2230-480X.
8. Muhammad Younus Dar, TabassumAra and Seema Akbar. Isolation of Daphnetin from Daphne oleoidesand its HPLC Finger Printing. Elixir Org. Chem. 91 (2016) 37992- 37994. ISSN: 2229-712X.
9. Ahlam Mushtaq, Seema Akbar, Mohammad A. Zargar, Adil F. Wali, Akhtar H. Malik,Mohammad Y. Dar, Rabia Hamid, and Bashir A. Ganai. Phytochemical Screening, Physicochemical Properties, Acute Toxicity Testing and Screening of Hypoglycaemic Activity of Extracts of Eremurus himalaicus Baker in Normoglycaemic Wistar Strain Albino Rats. Hindawi Publishing Corporation BioMed Research International Volume 2014, Article ID 867547, 6 pages
10. Rafia Rasool , Bashir Ahmad Ganai , Seema Akbar , Azra Nahaid Kamili , Muhammad Younus Dar and Akbar Masood.Variation in bioactive principles of Artemisia amygdalina Decne. in wild and tissue culture regenerants.Pak. J. Pharm. Sci., Vol.26, No.3, May 2013, pp.623-628
11. Mudasir A. Tantrya, Saba Shah, Mohammad Y. Dar,Mohammad M. Mir, Khalid Ghazanfar, Faheem A. Sheikh, Mohammad A. Khuroo & Seema Akbar. 9, 10-seco-9,19- cyclolanostane triterpene from Salix caprea L. (Goat Willow). Journal of Natural Product Research. 27:2, 171-175, 2012 Mar 8.
12. Khalid Ghazanfar Mustafa, Bashir A. Ganai, Seema Akbar, Mohammad Y. Dar, Akbar Masood, and Mudasir A. Tantry. β- cell protective efficacy, hypoglycemic and hypolipidemic effects of extracts of Achilleamillifolium in diabetic rats. Chinese Journal of Natural Medicines 2012, 10(3): 0185−0189
13. Khalid Ghazanfar, Bashir A. Ganai, Seema Akbar, Khan Mubashir, Showkat Ahmad Dar, Mohammad Younis Dar, and Mudasir A. Tantry. Antidiabetic Activity of Artemisia amygdalinaDecne in Streptozotocin Induced Diabetic Rats. BioMed Research International. Volume 2014, Article ID 185676. http://dx.doi.org/10.1155/2014/185676

Papers Presented in Seminars/Conferences.

1. Paper presented (Poster), on ‘Pharmacognostical, Phytochemical and Chromatographic Standardization of Ispand-A Classical Unani Drug’ at an International Conference on Communication and Dissemination of Traditional Knowledge(CDTK-2023) ON 14TH and 15th February 2023 organised by CSIR-National Institute of Science Communication and policy Research(CSIR-NIScPR), NewDelhiat A P Shinde Hall, NASC Compiex New Delhi.
2. Mohammad Younus Dar, Seema Akbar,Khalid Ghazanfar Mustafa. Determination of heavy metal ion toxicity in herbal medicine by Atomic Absorption Spectroscopy (AAS). 4th National symposium on recent advices in analytical sciences and applications.JamiaHamdard, New Delhi, Feb 9-10, 2015. p. 50.
3. Khalid Ghazanfar, Bashir A. Ganai, Seema Akbar, Khan Mubashir, Showkat Ahmad Dar, Mohammad Younis Dar, and MudasirA. Tantry. GentianakurooRoyle- a natural alternative remedy for diabetes.International Symposium on “Biodiversity: Status, Utilizationand Impact of ChallengingClimatic Conditions”Organized byBabasahebBhimraoAmbedkar University, IndiaOctober 30-31, 2014, p. 213
4. Ajaz Ahmed, Wajahat A. Shah, Seema Akbar, SofiMubashir, Mohammad Younis and Khalid Ghazanfar Mustafa. Salix alba: Effect of climatic variation on physiochemical parameters from its leaves. 9th J&K Science Congress, October 1st to 3rd, 2013, p. 150.
5. Ajaz Ahmed, Wajahat A. Shah, Seema Akbar, SofiMubashir, Mohammad Younis and Khalid Ghazanfar Mustafa. A short review on Aflotoxins contamination: An emerging problem. 9th J&K Science Congress, OcOctober 1st to 3rd, 2013, p. 150.
6. Khalid Ghazanfar Mustafa, Seema Akbar, Showkat Ahmad Dar, TazeenNazir and Mohammad Younis Dar. Subacute oral toxicity of Unani drug –UNIM –K-2019 in Albino wistar rats. 9th J&K Science Congress, October 1st to 3rd, 2013, p. 319.
7. Khalid Ghazanfar Mustafa, Bashir Ahmad Ganai, Seema Akbar, Showkat Ahmad Dar, Mudasir Ahmad Tantry, TazeenNazir, ArshidIqbal, Mohammad Younis Dar and Akbar Masood. Diabetes and medicinal plants-A review. 9th J&K Science Congress, October 1st to 3rd, 2013, p. 319.
8. Khalid Ghazanfar Mustafa, Seema Akbar and Mohammad Younis Dar.Acute, Subacute and Subchronic toxicity of Unani drug –UNIM –K-2004.8th J&K Science Congress, September 17th to 19th, 2012, p.170
9. Khalid Ghazanfar Mustafa, Seema Akbar,Bashir Ahmad Ganai, Mohammad Younis Dar and MudasirAhmad Tantry. Pre-clinical/Non-clinical studies in traditional drug development- A prerequisite. 8th J&K Science Congress, September 17th to 19th, 2012, p.28.
10. Seema Akbar, Mudasir Ahmad Tantry,Mohammad Younis Dar,Maqbool Mir,andKhalid Ghazanfar Mustafa. Chemical investigations of ITA-06- A standardized Unani prescription. 8th J&K Science Congress, September 17th to 19th, 2012, p. 472
11. Mohammad Younis Dar, Seema Akbar, Ajaz Ahmed and Khalid Ghazanfar. High performance liquid chromatography finger prints technology in herbal medicine. 8th J&K Science Congress, September 17th to 19th, 2012, p. 455
12. Mohammad Younis Dar,Seema Akbar, Shamshad Ahmad Khan, Khalid Ghazanfarand Ajaz Ahmad Malik. Verbascumthapsus – A new source of Diosgenin.. 7th J&K Science Congress, Oct. 13 to 15, 2011, p. 124.
13. Ajaz Ahmed, Wajaht A Shah, Seema Akbar,SofiMubashir,Mohammad Younis,Khalid Gazanfar. Anti-inflammatory andAntioxidant potential of Aromaticwater from Salix caprea. 7th J&K Science Congress, Oct. 13 to 15, 2011, p. 131.
14. Khalid Ghazanfar Mustafa, Bashir A.Ganai, Seema Akbar, Mohamad Y. Dar,Akbar Masood and Mudasir A. Tantry. Antidiabetic activity of extracts of Berberislycium in Alloxan-induced diabetes mellitus. 6th J&K Science Congress, Dec. 02 to 04, 2010, p. 208
15. Khalid Ghazanfar Mustafa, Seema Akbar, Bashir A. Ganai, Mohamad Y. Dar, Akbar Masood and Mudasir A. Tantry. A Study on the hypoglycemic and hypolipidemic effects of extracts of Achelliamillifolium in diabetic rats. 6th J&K Science Congress, Dec. 02 to 04, 2010, p. 211

No & Title of IMR Project of IMR Project Submitted as PI=01:
Quality control evaluation, phytochemical profiling and in-vitro anti-inflammatory activity of compound unani formulation- Habb-e –Gul-e –Aak/Accepted

No of Papers Published in Scientific Journals as as First Author=04
No of Papers Published in Scientific Journals as as Co-Author=10
No of Invited Talks/Papers Presented Iin Seminars/Conferences=14
Number of SOP’S Developed for compound/Single drugs=06
No of single/compound drugs Standardized 100+
No of Phytochemicals isolated from single Unani Drugs=20
No of MD/PhD Thesis (Co-Guide): MD=06;PhD=04